aggregation activities antiplatelet

New Copper Compounds with Antiplatelet Aggregation ...

Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a ...

Frontiers | Antiplatelet and Antithrombotic Activity of a ...

 · The current study demonstrated that HRT treatment clearly elicited antiplatelet and antithrombotic activities in mice. Importantly, we have determined that HRT regulates the phosphorylation of PLC and AKT in response to thrombin and CRP stimulation, which thereby regulates granule secretion, TXB 2 generation, Ca 2+ mobilization, and aggregation.

Alkaloids from Houttuynia cordata and Their Antiplatelet ...

 · Antiplatelet aggregation test indicated significant inhibitory activities of compounds 1, 2, 4-7, 9 induced by ADP and 1, 2, 4, 7 induced by thrombin. CONCLUSION: Compounds 2, 6, 7, 9 …

Synthesis and Antiplatelet Aggregation Activity Evaluation ...

 · Abstract. A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib ...

Antiplatelet and Antioxidant Activities of Tomato

 · Antiplatelet and Antioxidant Activities of Tomato. Abdul Waheed Khan 1,, Kashif Iqbal 1, Sagheer Ahmed 2,, Saima Gul 3, Arif-ullah Khan 4, Muhammad Usman 1 and Hafsa Bibi 5. 1 Department of Pharmacy, University of Lahore, Islamabad, Pakistan. 2 Shifa College of Pharmaceutical Sciences, Shifa Tameer-E-Millat University, Islamabad, Pakistan.

Synthesis and Antiplatelet Aggregation Activities in Vitro ...

Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities Eur J Pharmacol. 2007 Jul 2;566(1-3):137-44. doi: …

Anti-inflammatory, Antiplatelet Aggregation, and ...

 · The biological activities of all isolates were evaluated using four types of bioassays including cytotoxicity, anti-inflammatory, antiplatelet aggregation, and antiangiogenesis activities. Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis activities…

Studies on the antiplatelet and antithrombotic profile of ...

exhibiting antiplatelet and antithrombotic activities, in addition to the already known anti-inflammatory and antioxidant activities. Among others, compounds 15 and 16 were found to be the most potent and selective inhibitors of platelet aggregation whereas compound 3 also proved to be the most potent in the clot retraction assay.

New Copper Compounds with Antiplatelet Aggregation ...

Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong intramolecular hydrogen bond. NMR studies show that both ligands are found as enol-imine tautomers in …

Anti-inflammatory, Antiplatelet Aggregation, and ...

 · The biological activities of all isolates were evaluated using four types of bioassays including cytotoxicity, anti-inflammatory, antiplatelet aggregation, and antiangiogenesis activities. Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis activities, and ...

(PDF) Design, Synthesis, and In Vitro Antiplatelet ...

The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate.

Antiplatelet aggregation and antithrombotic benefits of ...

 · Particularly, compounds 10 and 24 inhibited ADP-induced platelet aggregation and delayed FeCl 3-induced thrombus in zebrafish. Furthermore, interactions between compounds 10 and 24 with two ADP receptors P2Y 1 and P2Y 12, serving as the target for key regulators of antiplatelet aggregative activity, were investigated via molecular modeling.

Antiplatelet and Antithrombotic Activities of Non ...

The antiplatelet activities of NAH have been described in previous studies [20]. Several studies have shown that the presence of this subunit enhances antiplatelet activity [21–23]. The NAH subunit is thought to inhibit antiplatelet activity because of its high affinity for COX-1 and greater inhibition of

Antiplatelet Aggregation Activity of a Fraction Isolated ...

ABSTRACT A fraction isolated from crude aqueous extract of Galega officinalis L. and purified by column chromatography inhibit platelet aggregation in platelet-rich plasma. The active fraction of the extract, molecular weight of 100–140 kDa, appeared to be polysaccharide-protein complex. Aggregation of platelets initiated by 25 μM ADP was inhibited 50 percent by 11.2 μg/ml of the fraction.

Synthesis, Antiplatelet Aggregation Activity Evaluation ...

 · A series of novel 6‐alkylamino(alkoxyl)‐2‐propylthio‐8‐azapurine nucleosides were synthesized by an improved route, and the human antiplatelet aggregation activities of these new compounds were evaluated.

Quinoline Alkaloids and Other Constituents of Melicope ...

Several of these isolates were determined as exhibiting significant antiplatelet aggregation activities in vitro. * To whom correspondence should be addressed. Tel: (886) 73121101, ext. 2191. Fax: (886) 73210683. E-mail: [email protected] kmu .tw. † ...

Research and Revies: Journal of Pharmacy and ...

exhibited higher antiplatelet aggregation activities than picotamide [5]. After 2005, in continuation of our interest on the synthesis of related compounds N,N''-disubstitutedphenyl-4-methoxyl-benzene-1,3-disulfonamidesseries of series 2 (Figure 1) [6-8], it is based on that benzene-1,3-disulfonamide is the isostere of isophthalamide.

Antiplatelet aggregation activity of diterpene alkaloids ...

 · Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. Li L(1), Shen YM, Yang XS, Zuo GY, Shen ZQ, Chen ZH, Hao XJ. Author information: (1)Kunning Instiute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, PR China.

Synthesis of 3,15-Disuccinate-12-Coumarin Substituted ...

 · The activities of 3′-substituted derivatives (11b-11d) were higher than the 6′-substituted (11e-11h) and 7′-substituted (11i-11l). When chloro group attaching to 3′, 6′, 7′ positions, antiplatelet aggregation activities also subsided.

Research Article Design, Synthesis, and In Vitro ...

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. e in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. e results showed that the target compound f had potent antiplatelet aggregation activity with its IC ...

In Vitro Antiplatelet Aggregation Activity of Centella ...

naturally derived antiplatelet aggregation with fewer side effects. From in vitro study, Centella asiatica (CA) has been known to have some pharmacodynamic activities such as wounds healing3, anti peptic ulcer4, mental disorders, antiviral, fungicidal, antibacterial and many others5. CA

Synthesis and the Evaluations in vitro Antiplatelet ...

The results revealed, among the series 2, six compounds 200, 2a, 2k, 2n, 2q and 2r displayed good antiplatelet aggregation activities in vitro induced by 5.0 mM ADP with IC50 values ranging over …

Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities o…

Foods to Decrease Platelet Aggregation | LIVESTRONG

In Vitro Antiplatelet Aggregation Activity of Aqueous and ...

platelet activation and aggregation. In this study, antiplatelet aggregation activities of aqueous and alcoholic extracts of AILE were performed at the concentration of 200, 400 and 800 µg/ml respectively. The effect of extracts at different concentrations were measured and compared with the standard drug aspirin (Table 1).

Antithrombotic and antiplatelet activities of pelargonidin ...

 · Mode of action of pelargonidin for antithrombotic and antiplatelet effects was (1) inhibiting intrinsic and extrinsic coagulation pathway, (2) inhibiting fibrin polymerization, (3) inhibiting platelet aggregation, (4) suppression of thrombin and FXa activities and production, and (5) reducing PAI-1/t-PA ratio (Fig. 4 ).

The Antiplatelet Activity of Aspirin

The Antiplatelet Activity of Aspirin of thromboxane A 2 occurs in response to a variety of stimuli, resulting in irreversible platelet aggregation. Platelets, platelet products and thombosis play important roles in the occurrence of acute occlusive vascular events, including myocardial infarction (MI) …

Design, Synthesis, and In Vitro Antiplatelet Aggregation ...

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC<sub>50</sub> 27.6&#x2009;<i>&#x3BC;</i>mol/L ...

Design, Synthesis, and In Vitro Antiplatelet Aggregation ...

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation …

Chemical constituents from heartwoods of Caesalpinia ...

 · Antiplatelet aggregation activities assay. Institute of Cancer Research (ICR) mice (male, 30−40 g) were obtained from Nanjing Qinglongshan Animal Center (Nanjing, Jiangsu, China). The animals were acclimatized for at least 1 d prior to use. Mouse gel-filtered platelets were prepared as described previously (Su et al., 2016). Briefly, the mice ...

Antiplatelet, Antithrombotic, and Fibrinolytic Activities ...

Hence, the C. xanthocarpa extract with a combination of antiplatelet aggregation, antithrombotic, and fibrinolytic activities may be effective in preventing thrombus formation through several pathways. Saponins are widely distributed in plants and have many biological activities, such as antiplatelet …

New Copper Compounds with Antiplatelet Aggregation Activity

Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong …

Antiplatelet aggregation activity of diterpene alkaloids ...

 · 3.3.. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirinA comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.